Villarreal reached this stage of the competition having participated in three rounds, picking up wins against Santa Amalia [9-0], CD Guijuelo [2-1 AET], and FC Cartegana [5-1].
The Yellow Submarine and Los Blancos clash for the second time this year and season, with Quique Setién’s side picking up a win in their league meeting this month.
Here are some betting tips from this heavyweight Copa Del Rey round of 16 fixture.
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