After scoring thrice in each other of their Manchester derby games against Manchester United in the Premier League, including the 3-1 victory at the weekend, Pep Guardiola’s men will look to do the double against the Danish side to progress into the UCL quarters.
Copenhagen come into the tie on the back of a 2-0 league loss at Midtjylland.
Jack Grealish is ruled out with a groin problem, while Josko Gvardiol has made a comeback to the squad after recovering from an ankle injury.