Nadal was forced to skip the Masters 1000 event in Indian Wells last month as well as the Miami Open that ended last week, as he continues his recovery from a hip issue that ended his Australian Open title defence in the second round in January.
“Unfortunately I am still not ready to compete and will miss one of those special tournaments I always love to play,” Nadal said in a statement.
“Monte Carlo is and has been a key event in my career, but unfortunately I will have to miss it again since I am still not ready to compete without the risk of getting injured. I will continue the process of getting ready to come back.”